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Elective Single Embryo Transfer (SET): Benefits, Procedure, and Success Rates

Last updated: November 28, 2025

Overview

Elective Single Embryo Transfer (SET) is a safer IVF option that limits the number of embryos transferred to a single high-quality embryo. Thus, it eliminates complications associated with multiple pregnancies. This article describes the advantages, process, success rates, and candidates for SET. So couples can make informed and safe choices about fertility treatment.

What is Elective Single Embryo Transfer?

Elective Single Embryo Transfer (SET) refers to transferring only one healthy embryo during an IVF cycle. SET focuses on quality over quantity, making sure that the healthiest, most viable embryo is selected.

Clinics recommend single embryo transfer IVF because it significantly reduces the risk of multiple pregnancies. A common complication is when two or more embryos implant together. SET aims to eliminate this, as multiple pregnancies turn out to be risky for both mother and baby.

Why Choose Single Embryo Transfer in IVF?

SET in IVF is becoming a preference because:

  • Reduction in the risk of Multiple Pregnancies Although twins and triplets can be a reason for celebration. They also increase the risk of complications ranging from preterm delivery to hypertension and low birth weight.
  • It Is Safer for Both Mother and Baby Mothers typically have healthier pregnancies with more predictable outcomes. Since there are fewer pregnancy complications associated with single embryo transfer (SET),
  • It Helps in Achieving a Healthy Pregnancy It supports the achievement of a healthy, term pregnancy by allowing embryos to implant naturally. Thus, giving mothers a greater likelihood of reaching the end of their term.

Procedure of Elective Single Embryo Transfer

The Single Embryo Transfer (SET) process operates in accordance with the standard In Vitro Fertilisation (IVF) pathway; however, instead of using the typical embryo selection method, embryo selection is achieved in a much more targeted manner.

  • Step 1: Ovarian Stimulation & Egg Retrieval The use of fertility medications to stimulate the ovaries results in multiple follicles maturing. After stimulation is completed, the eggs are collected from the ovaries via a simple outpatient procedure.
  • Step 2: Fertilisation in the Lab The retrieved eggs are fertilised using IVF or ICSI in the formation of embryos.
  • Step 3: Embryo Culture & Selection After the embryos have developed for a few days, they are monitored by a specialist. At this point, the specialist will evaluate the embryos according to their quality or development into Blastocysts. The highest quality embryo will be selected to transfer. This is what sets SET apart from other IVF methods; hence the name.
  • Step 4: Embryo Transfer Once the embryo has been selected, it will be placed back into the uterus using a very thin catheter.
  • Step 5: Post-Transfer Care & Monitoring Supporting the hormones, advising on lifestyle management, and doing an early ultrasound scan will provide support for the optimal conditions for placing embryos in the uterus.

Success Rates of Single Embryo Transfer

The success behind the Single Embryo Transfer (SET) is dependent upon several fertility factors. Younger women generally have higher chances of implantation and pregnancy. This is as age strongly influences egg health. In transferring well-developed blastocysts, embryo quality also plays a vital role, especially. A receptive and healthy uterine environment further boosts success. Underlying medical conditions, such as hormonal imbalances or reproductive disorders, may affect implantation. However, together, these factors determine how successful an SET cycle can be.

SET vs. Multiple Embryo Transfer

Research has shown that transferring only one high-quality embryo may yield a pregnancy outcome equal to the same level as the multiple embryo transfer technique. The only major distinction is the element of safety. When multiple embryos are implanted at once, the chance of having twins or multiples is increased. However, when multiple embryos are implanted, there is also an increased risk for preterm delivery, low birth weight, and maternal health concerns.

The strategy of using one embryo only (SET) prevents these potential complications by limiting the number of embryos implanted to just one. Therefore, it is a safer, more controllable, and more effective choice for most patients over time. For these reasons, success rates for single embryo transfers will be consistently reliable and much safer in the long term than the success rates of other assisted reproductive techniques.

Advantages of Elective Single Embryo Transfer

If you opt for SET, then get blessed with these important health and emotional benefits:

  • Lower Maternal Risks Gestational diabetes, pre-eclampsia and caesarean deliveries occur less often.
  • Decrease in Neonatal Risks Less likely to have pre-term births, low birth weights and NICU admissions.
  • Increased Control of the IVF Process SET provides certainty and, therefore, makes the continued pregnancy process more predictable and easier to manage. These advantages of single embryo transfusion lead to safer family planning.

Who Should Consider Elective SET?

SET is highly recommended for these groups:

  • Women with high-quality embryos, particularly blastocysts with high implantation potential.
  • Patients who are at high risk for multiple births as a result of their current medical condition may experience complications when a twin or triplet pregnancy occurs.
  • Patients who are 37 years of age or younger, or those who are undergoing their initial IVF cycle. Studies show that patients who meet these criteria will usually achieve a better outcome after completing their first or second IVF cycle because their eggs and embryos are generally of good quality.

Conclusion

Elective Single Embryo Transfer is a safe, effective, and modern IVF strategy that prioritises maternal and baby health. By reducing the likelihood of complications from multiple pregnancies while continuing to have high success rates, eSET has produced a scientifically sound solution that balances risks and benefits. Couples interested in seeking ART should talk to their physician or fertility clinic about the best option that provides the highest growth potential of achieving pregnancy while also minimising risk for both the mother and infant.

Common Questions Asked

What is the difference between single embryo transfer and multiple embryo transfer?

 

SET transfers only one embryo. While MET transfers two or more. MET increases the chances of twins or triplets.

Is single embryo transfer safer than transferring multiple embryos?

 

Yes. SET significantly lowers maternal complications and is a safer option for the baby.

How many IVF cycles may be needed with SET?

 

Many women conceive within 1–2 cycles. More so, if high-quality embryos are an option.

Can SET affect pregnancy chances compared to multiple embryo transfer?

 

Success rates are almost equal when the selected embryo is of good quality without the added risks.

What are the benefits of IVF SET?

 

Lower risks, healthier pregnancies, reduced preterm birth chances, and better maternal safety.

**Disclaimer: The information provided here serves as a general guide and does not constitute medical advice. We strongly advise consulting a certified fertility expert for professional assessment and personalized treatment recommendations.
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